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KMID : 1007320070130030192
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 3 p.192 ~ p.199
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Comparision and Standardization of Dual Energy X-ray Densitometry Systems
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Jung In-Cheul
Park Youn-Kyung
Kang Young-Hwa
Kwack Hyun-Sung
Kim Hyun-Jung
Choi Sae-Kyung
Cho Hyun-Hee
Kim Min-Jung
Hwang Sung-Jin
Song Jae-Yeon
Chan Bo-Ah
Kim Jang-Heub
Lee Jin-Woo
Kim Jin-Hong
Kim Mee-Ran
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Abstract
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Objectives: The Dual energy X-ray absorptiometry (DXA) has different results in reported bone mineral density (BMD) among manufactures, system and measurement site, so called T-score discrepancy. In this study, the comparision and standardization between DXA systems was obtained. Consequently evaluation of the cross calibration formaula and Korean reference database was also obtained.
Methods: A total of 100 Korean women were recruited and studied between September 2006 and February 2007 in Kangnam St. Mary’s Hospital, the Catholic University of Korea. The BMD was measured in the lumbar vertebrae (L1-4) and the both femoral neck one the same day using a GE Lunar Prodigy and Hologic QDR-4500. We compared the BMD values, T-scores, Z-scores and patients’ diagnoses based on WHO criteria between two systems. We calculated standardized BMD (sBMD) and compared Lunar to Hologic. This study evaluate and calculate new conversion formula between Lunar and Hologic DXA for Korean women.
Results: Both the L-spine and the femur neck, the Lunar yielded consistently higher results than the Hologic (P＜0.001). The BMD values measured by the two instruments were highly correlated (lumbar spine r=0.97, femur neck r=0.95 , P＜0.01). The sBMD values by the conversion formula which were compared with BMD measured, had significant differnces in lumbar spine (P＜0.01, paired t-test). New conversion formulas between two systems for Korean women are calculated. For the lumbar spine: Hologic=(0.844×Lunar)+ 0.006, for the femur neck: Hologic=(0.886×Lunar) 0.05.
Conclusion: For correcting the discrepancy of different DXA systems, we can use sBMD, cross calibration, and furthermore calculate new conversion formula for the reference population.
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KEYWORD
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Dual energy X-ray absorptiometry, Hologic, Lunar, Standardization
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